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Incretin-based therapies are effective glucose-lowering drugs that have an increasing role in the treatment of type 2 diabetes, due to their efficacy, safety, and ease of use.

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Lovshin, JA, Drucker DJ, Incretin-based therapies for type 2 diabetes mellitus. Nat Rev. Endocrinol. 2009;5:262-9. 7. Deacon et al. Dipeptidyl 

2006. Mar;3(3):153-65. Review. 7. Riddle M C, Drucker D J. Emerging therapies mimicking the ef-. Author : Yuedan Zhou; diabetes och endokrinologi Genomik; [] In addition, impaired incretin effect is likely a part of the pathogenesis of T2D. Stem cell in-vitro strategies for the induction of sensory neurons for inner ear cell therapy. cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes.

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Diabetes. Ther 2011; 2(2): 101–121. 13. Together, obesity and diabetes form a 21st century epidemic, the treatment of which consumes a substantial fraction of global health costs. New and improved  The aim of the present study was to examine the effects of incretin-based therapy on cognitive performance in type 2 diabetes patients  DPP-4 Inhibition Islet- and Incretin Hormones in Health and Type 2 Diabetes Glucagon Counter-Regulation to Hypoglycemia During Incretin-Based Therapy.

According to data from the International Diabetes Federation, globally 425 million people had diabetes in 2017, which represents 8.8% of the world’s population, and type 2 diabetes accounts for 90% of all cases.Although the condition is massively prevalent on a global scale, prompting no small investment in drug development, there are EXPERT OPINION: Incretin-based therapy may have a role in the treatment of diabetic foot ulcers; the benefits of such treatment arise from attenuation of inflammatory response, improvement of keratinocyte migration, induction of angiogenesis, and the enhancement of tissue remodeling.

There is a reduction of the incretin effect in individuals with type 2 diabetes, which can be rectified through the administration of exogenous native GLP-1. 3,4 Hence, continuous intravenous infusion of GLP-1 in subjects with type 2 diabetes increases insulin secretion, reduces glucagon secretion, and lowers plasma glucose. 5 The effect of GLP-1 is glucose-dependent, so despite ongoing

J Am Coll Cardiol 2016;67:1488-1496. The following are key points to remember from a review on incretin-based therapy for diabetes: 2009-10-30 · Incretin hormone is a hormone that stimulates insulin secretion in response to meals. The two most important incretin hormones are called glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).

Incretin therapy for diabetes

is used as a HYPOGLYCEMIC AGENT and supplemental therapy in the treatment of DIABETES MELLITUS by patients who do not respond to METFORMIN.

Incretin therapy for diabetes

Although they represent different approaches to therapy in patients with type 2 diabetes, there are notable similarities (Table 1). Incretin-based therapies are effective glucose-lowering drugs that have an increasing role in the treatment of type 2 diabetes, due to their efficacy, safety, and ease of use.

Incretin therapy for diabetes

15 Amori, R.E., J. Lau, and A.G. Pittas, Efficacy and safety of incretin therapy in type 2  Impact of Intensive Therapy for Diabetes: Holst JJ, Gromanda J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic  Lovshin, JA, Drucker DJ, Incretin-based therapies for type 2 diabetes mellitus. Nat Rev. Endocrinol. 2009;5:262-9.
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Due to their promising action on insulinotropic secretion and improving insulin resistance (IR), incretin-based therapies have become a new class of antidiabetic agents for the treatment of type 2 diabetes mellitus (T2DM). Incretin therapy is an exciting novel glucose-lowering therapy in type 2 diabetes. It targets the dysfunction of the pancreatic islets, which is the pathophysiology of the disease, and it reduces both fasting and postpran - dial glucose with at the same time a very low risk for hypoglycaemia and no weight gain. Incretin therapy is based on the Incretin mimetics Exenatide

  • The first incretin-related therapy available for patients with type 2 diabetes.